Daniel F. Carlson,Scott C. Fahrenkrug,Dennis Webster
申请号：
US15711920
公开号：
US20180084767A1
申请日:
2017.09.21
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Genomically modified livestock animals having a modification in one or more genes implicated in heart failure are provided. The animals provide models for various pathologies in heart failure including dilated cardiomyopathy and hypertrophic cardiomyopathy and can be used for investigation of new treatment methods including interventional devices, biologics and pharmaceuticals. The models can also be induced to develop metabolic syndrome (MetS) and are therefore amenable to further investigation of the confounding effects of MetS on the progress of heart failure.
