EASTMAN, Kyle J.,KADOW, John F.,ZHANG, Zhongxing,WANG, Tao,YIN, Zhiwei,PARCELLA, Kyle E.
申请号：
PE0016482016
公开号：
PE12242016A1
申请日:
2015.03.20
申请国别(地区):
PE
年份:
2016
代理人:
摘要：
The present Invention relates to compounds of formula I or a pharmaceutically acceptable salts where z is C - R5 is H OR N R0, R1 is methyl phenyl, R2 is replaced with 0 - 2 Halo or methoxy or is replaced with W AR W is - or or - NH - ar is phenyl or - halofenilo R3 is Hydrogen, Fluorine or clo Ro R4, R5 and R6 are h, halos, among others R7b R7a, are h, AR1,Among other R7b or R7a and form a Ring carbociclico 3 - 7 Elements R8 is h AR1 is phenyl, among others R9 is Hydrogen, Halo, among others.Preferred compounds are (R) - 5 - (3 - ((1 - cyano - 1-cyclopropylethyl) Carbamoyl) - 4-fluorophenyl) - 2 - (4-fluorophenyl) - n-methyl - (6) - trifluoropropil) furo [2,3-b] pyridin - 3 - carboxamide (S) - 5 - (3 - ((1 - cyano - 1-cyclopropylethyl) Carbamoyl) - 4-fluorophenyl) - 2 - (4-fluorophenyl) - n-methyl - (6) - trifluoropropil furo [2,3-b) ] pyridin - 3 - carboxamide. It also relates to a Composition and a method of treatment.These compounds have activity against hepatitis C virus, being useful in the treatment of patients infected with this virusLa presente invencion se refiere a compuestos de la formula I o sales farmaceuticamente aceptables donde Z es C-R5 o N R0 es H R1 es metilo R2 es fenilo sustituido con 0-2 halo o metoxi, o es para sustituido con W-Ar W es -O- o -NH- Ar es fenilo o para-halofenilo R3 es hidrogeno, fluoro o cloro R4, R5 y R6 son H, halos, entre otros R7a, R7b son H, Ar1, entre otros o R7a y R7b forman un anillo carbociclico de 3-7 elementos R8 es H Ar1 es fenilo, entre otros R9 es hidrogeno, halo , entre otros. Son compuestos preferentes (R)-5-(3-((1-ciano-1-ciclopropiletil)carbamoil)-4-fluorofenil)-2-(4-fluorofenil)-N-metil-6-(3,3,3-trifluoropropil)furo[2,3-b]piridin-3-carboxamida (S)-5-(3-((1-ciano-1-ciclopropiletil)carbamoil)-4-fluorofenil)-2-(4-fluorofenil)-N-metil-6-(3,3,3-trifluoropropil)furo[2,3-b]piridin-3-carboxamida. Tambien se refiere a una composicion y un metodo de tratamiento. Dichos compuestos tienen actividad contra el virus de l
