WANG, Tao,EASTMAN, Kyle J.,ZHANG, Zhongxing,PARCELLA, Kyle E.,YIN, Zhiwei,KADOW, John F.
申请号：
ES15714137
公开号：
ES2688554T3
申请日:
2015.03.20
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound of Formula I, which includes pharmaceutically acceptable salts thereof: ** Formula ** in which Z is C-R5 or N； R0 is hydrogen； R1 is methyl； R2 is phenyl that is independently substituted with 0-2 halo or methoxy, or is substituted in place for with W-Ar； W is -O- or -NH-； Ar is phenyl or para-halophenyl； R3 is hydrogen, fluorine or chlorine； R4, R5, and R6 are independently selected from the group of hydrogen, halo, alkyl, haloalkyl, alkoxy and perdeuteroalkoxy； R7a, R7b are each independently selected from the group of hydrogen, alkyl, cycloalkyl and Ar1, or together R7a and R7b form a 3-7 membered carbocyclic ring； R8 is hydrogen, Ar1 is phenyl, a 5-membered heteroaromatic ring or a 6-membered heteroaromatic ring； R9 is hydrogen, halo, R201, OR202, NR203R204； R201 is alkyl, alkenyl or C1-C4 alkyl with between one and all fluorine replaced hydrogens； R202 is C1-C3 alkyl or C1-C3 alkyl with between one and all fluorine replaced hydrogens； R203 is hydrogen； and R204 is C1-C3 alkyl or C1-C3 hydroxyalkyl or is C1-C3 alkyl with between one and all fluorine-replaced hydrogens.Un compuesto de Fórmula I, que incluye sales farmacéuticamente aceptables del mismo:**Fórmula** en la que Z es C-R5 o N； R0 es hidrógeno； R1 es metilo； R2 es fenilo que está independientemente sustituido con 0-2 halo o metoxi, o esta sustituido en posición para con W-Ar； W es -O- o -NH-； Ar es fenilo o para-halofenilo； R3 es hidrógeno, flúor o cloro； R4, R5, y R6 se seleccionan independientemente entre el grupo de hidrógeno, halo, alquilo, haloalquilo, alcoxi y perdeuteroalcoxi； R7a, R7b se seleccionan cada uno independientemente entre el grupo de hidrógeno, alquilo, cicloalquilo y Ar1, o juntos R7a y R7b forman un anillo carbocíclico de 3-7 miembros； R8 es hidrógeno, Ar1 es fenilo, un anillo heteroaromático de 5 miembros o un anillo heteroaromático de 6 miembros； R9 es hidrógeno, halo, R201, OR202, NR203R204； R201 es alquilo, alquenilo o alquilo C1-C4 con entre uno y todos los hidrógeno
