PROBLEM TO BE SOLVED: To provide a method for treating intractable hematologic malignancy.SOLUTION: A method includes administering a proteasome inhibitor according to the following formula or another specific proteasome inhibitor, or pharmacologically acceptable salts thereof, and a PIM kinase inhibitor or pharmacologically acceptable salts thereof.SELECTED DRAWING: NoneCOPYRIGHT: (C)2020,JPO&INPIT【課題】難治性の血液悪性腫瘍を治療する方法の提供。【解決手段】下式、又は他の特定のプロテアソーム阻害剤、又はその薬学的に許容される塩、及びPIMキナーゼ阻害剤又はその薬学的に許容される塩を投与することを含む方法。【選択図】なし