Urs BAETTIG,Kamlesh Jagdis Bala,Emma Budd,Lee Edwards,Catherine Howsham,Glyn Alan Hughes,Darren Mark LE GRAND,Katrin Spiegel
申请号：
US16143202
公开号：
US20190262324A1
申请日:
2018.09.26
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present invention provides pyridine and pyrazine derivatives which restore or enhance the function of mutant and/or wild type CFTR to treat cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory tract infections, lung carcinoma, xerostomia and keratoconjunctivitis sire, or constipation (IBS, IBD, opioid induced). Pharmaceutical compositions comprising such derivatives are also encompassed.
