BAETTIG, Urs,BALA, Kamlesh Jagdis,BUDD, Emma,EDWARDS, Lee,HOWSHAM, Catherine,HUGHES, Glyn,LEGRAND, Darren Mark,SPIEGEL, Katrin
申请号：
TN2012000446
公开号：
TN2012000446A1
申请日:
2012.09.17
申请国别(地区):
TN
年份:
2014
代理人:
摘要：
The present invention provides pyridine and pyrazine derivatives which restore or enhance the function of mutant and/or wild type CFTR to treat cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory tract infections, lung carcinoma, xerostomia and keratoconjunctivitis sire, or constipation (IBS, IBD, opioid induced). Pharmaceutical compositions comprising such derivatives are also encompassed.
