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Monoclonal antibodies against claudin-18 for cancer treatment
专利权人:
Astellas Pharma Inc.;TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人:
Sahin, Ugur,Türeci, Özlem,Usener, Dirk,Fritz, Stefan,Uherek, Christoph,Brandenburg, Gunda,Geppert, Harald-Gerhard,Schröder, Anja Kristina,Thiel, Philippe
申请号:
ES10011772
公开号:
ES2689746T3
申请日:
2006.11.24
申请国别(地区):
ES
年份:
2018
代理人:
摘要:
A monoclonal antibody comprising an allotypic modification in the heavy chain of the antibody, wherein the antibody comprises a combination of heavy chains and light chains selected from the following possibilities (i) to (ix): (i) the heavy chain comprises a sequence of amino acids represented by SEQ ID NO: 115 and the light chain comprises an amino acid sequence represented by SEQ ID NO: 122, (ii) the heavy chain comprises an amino acid sequence represented by SEQ ID NO: 116 and the chain The light chain comprises an amino acid sequence represented by SEQ ID NO: 121, (iii) the heavy chain comprises an amino acid sequence represented by SEQ ID NO: 117 and the light chain comprises an amino acid sequence represented by SEQ ID NO: 123, (iv) the heavy chain comprises an amino acid sequence represented by SEQ ID NO: 119 and the light chain comprises an amino acid sequence represented by the SEQ ID NO: 126, (v) the heavy chain comprises an amino acid sequence represented by SEQ ID NO: 118 and the light chain comprises an amino acid sequence represented by SEQ ID NO: 125, (vi) the heavy chain comprises an amino acid sequence represented by SEQ ID NO: 120 and the light chain comprises an amino acid sequence represented by SEQ ID NO: 124, (vii) the heavy chain comprises an amino acid sequence represented by SEQ ID NO: 120 and the light chain comprises an amino acid sequence represented by SEQ ID NO: 127, (viii) the heavy chain comprises an amino acid sequence represented by SEQ ID NO: 120 and the light chain comprises an amino acid sequence represented by SEQ ID NO: 128, and (ix) the heavy chain comprises an amino acid sequence represented by SEQ ID NO: 120 and the light chain comprises an amino acid sequence represented by SEQ ID NO: 129; wherein said heavy chain comprises the amino acid sequences of SEQ ID NO: 46 and the allotypic modification is a replacement for K93R, D235E and L237M within the amino acid sequence of SEQ ID NO: 46.Un anticuerpo monoclonal que comprende
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