A reusable clamp (10) for retaining conduit sections (12) or sanitary fittings having circular flanges (14) together includes two gland members (20, 22) movable between open and closed positions. The gland members (20, 22) include two handles (56, 64) projecting outwardly from the gland members (20, 22) and two sets of locking detents (76, 78) formed on a latch finger (74) connected to one gland member (20) and the outer periphery (48) of the other gland member (22). The locking detents (76, 78) engage to prevent movement of the gland members (20, 22) away from the closed position until a latch release arm (18) coupled to the latch finger (74) is depressed towards one of the handles (56, 64), which causes the locking detents (76, 78) to disengage from one another and enables re-opening of the clamp (10) when desired. The latch release arm (18) and one or more of the handles (56, 64) also include tie-receiving loops (104, 106) to prevent accidental opening of the clamp (10) unless desired by the end user.