36 ABSTRACT INHALABLE DRUG A PROCESS FOR PREPARATION OF PARTICLES OF AN INHALABLE DRUG IS DESCRIBED. THE PROCESS COMPRISES COMBINING A FIRST LIQUID AND A SECOND LIQUID IN A REGION OF HIGH SHEAR, WHEREBY THE FIRST LIQUID AND THE SECOND LIQUID INTERACT TO FBINN THE PARTICLES OF THE DRUG. ONE OF THE FIRST AND SECOND LIQUIDS COMPRISES THE DRUG OR A PRECURSOR THEREOF. IN THE CASE WHERE ONE OF THE LIQUIDS COMPRISES THE PRECURSOR, THE OTHER OF THE FIRST AND SECOND LIQUIDS COMPRISES A REAGENT WHICH REACTS WITH THE PRECURSOR UNDER HIGH SHEAR CONDITIONS TO FORM PARTICLES OF THE DRUG. IN THE CASE WHERE ONE OF THE LIQUIDS COMPRISES THE DRUG, THE OTHER OF THE FIRST AND SECOND LIQUIDS COMPRISES A LIQUID WHICH, WHEN MIXED WITH THE LIQUID CONTAINING THE DRUG UNDER HIGH SHEAR, FORMS PARTICLES OF THE DRUG. FIG. 1 010
