MÉTHODE IN VITRO POUR LE PRONOSTIC OU LA PRÉDICTION DE LA RÉPONSE DE PATIENTS SOUFFRANT DE POLYARTHRITE RHUMATOÏDE AU TRAITEMENT AVEC DES AGENTS RECONNAISSANT LE RÉCEPTEUR MEMBRANAIRE CD 20 DES LYMPHOCYTES B
FUNDACIO INSTITUT DE RECERCA DE L'HOSPITAL UNIVERSITARI VALL D'HEBRON
发明人:
申请号：
EP10791644.7
公开号：
EP2447374B1
申请日:
2010.06.09
申请国别(地区):
EP
年份:
2014
代理人:
摘要：
In vitro method for the prognosis or prediction of response in patients with rheumatoid arthritis to treatment with agents recognising the B-lymphocyte CD20 membrane receptor. The method of the invention comprises an assay in a blood sample from these patients and measuring, before starting the treatment, the transcriptional expression level (mRNA) of at least one of the genes selected from the group: ARG1, CPD, TRAF1, C1QA, LRRN3, HLA-DQA1, NLK, TLR4, LOC89944, TOM1L1, BACH, NCALD, EIF2C2, NFIC, PCDHB7, FLJ32770, ARID3A, C140RF9, CSNK1E, BCAS1, TEAD2, C6orf145 and SNTA1； and the comparison of this expression level to the expression values previously obtained in patients who responded and who did not respond to the treatment.
