MULTIVALENT VLA-4 ANTAGONISTS COMPRISING POLYETHYLENE GLYCOL MOIETIES

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专利权人:

ELAN PHARMACEUTICALS; INC.

发明人:

KONRADI, ANDREI W

申请号：

NZ58883905

公开号：

NZ588839A

申请日:

2005.07.08

申请国别(地区):

NZ

年份:

2012

代理人:

摘要：

Provided are VLA-4 antagonists, with an exemplary structure (iia) as depicted. The compounds are conjugates of a bio-compatible polymer moiety and a branched-arm hub molecule and can comprise multiple polyethylene glycol moieties. The conjugate compounds can be alpha4beta1 or alpha4beta7 inhibitors and can be used to treat inflammation and autoimmune diseases.

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