Described herein are tetrahydro-pyrido[3,4-b]indol-1-yl compounds with estrogen receptor modulation activity or function having the Formula I structure: and stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the Formula I compounds, as well as methods of using such estrogen receptor modulators, alone and in combination with other therapeutic agents, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.本文描述具有式I結構之四氫-吡啶并[3,4-b]吲哚-1-基化合物，其具有雌激素受體調節活性或功能：及其立體異構體、互變異構體或醫藥學上可接受之鹽，且其具有本文所述之取代基及結構特徵。亦描述包括式I化合物之醫藥組合物及藥劑，以及使用單獨及與其他治療劑組合之此類雌激素受體調節劑用於治療雌激素受體介導性或依賴性疾病或病狀之方法。
