The present invention relates to a non-stick coated electrosurgical diathermy instrumentation, comprising: a handle portion an isolation tube, connected to the handle portion by one end thereof an instrument portion, connected to another end of the isolation tube, wherein an anti-sticking layer is formed on the surface of the instrument portion and an electrode, connected to the handle portion and an external conductive member. In the present invention, the instrument portion is able to generate heat when the conductive member conducts electricity to the instrument portion.