ANGIBAUD, PATRICK RENE,PILATTE, ISABELLE NOELLE C.,VAN BRANDT, SVEN FRANCISCUS ANNA,ROUX, BRUNO,TEN HOLTE, PETER,VERDONCK, MARC,MEERPOEL, LIEVEN,DYATKIN, ALEXEY B.
申请号：
ES03711980
公开号：
ES2371632T3
申请日:
2003.03.11
申请国别(地区):
ES
年份:
2012
代理人:
摘要：
A compound of formula (I), the N-oxide forms, the pharmaceutically acceptable addition salts 5 and the stereochemically isomeric forms thereof, in which: n is 0, 1, 2 or 3, and when n is 0, then a direct link is sought； t is 0, 1, 2, 3 or 4, and when t is 0, then a direct link is sought； R1 is -C (O) NH (OH)； R2 is hydrogen, halo, hydroxy, amino, nitro, C1-6 alkyl, C1-6 alkyloxy, trifluoromethyl, di (C1-6 alkyl) amino, hydroxyamino or naphthalenylsulfonylpyrazinyl； -L- is a direct link； each R3 independently represents a hydrogen atom, and a hydrogen atom can be substituted by a substituent chosen from aryl； R4 is hydrogen, hydroxy, amino, C1-6 alkyl hydroxy, C1-6 alkyl, C1-6 alkyloxy, aryl C1-6 alkyl, aminocarbonyl, hydroxycarbonyl, amino C1-6 alkyl, aminocarbonyl C1-6 alkyl, hydroxycarbonyl C1-6 alkyl, hydroxyaminocarbonyl, C1-6 alkyloxycarbonyl, C1-6 alkylamino C1-6 alkyl or di (C1-6 alkyl) amino C1-6 alkyl； in which each s is independently 0, 1, 2, 3, 4 or 5； each R5 and R6 are independently selected from hydrogen； halo； hydroxy； Not me； nitro； trihalo C1-6 alkyl； trihalo C1-6 alkoxy； C1-6 alkyl； C1-6 alkyl substituted with aryl and C3-10 cycloalkyl； C1-6 alkyloxy； C1-6 alkyloxy C1-6 alkyloxy； C1-6 alkylcarbonyl； C1-6 alkyloxycarbonyl； C1-6 alkylsulfonyl； C 1-6 alkyl cyano； C1-6 alkyl hydroxy； C1-6 alkyloxy hydroxy； C1-6 alkylamino hydroxy； C 1-6 alkyloxy amino； di (C1-6 alkyl) aminocarbonyl； di (C1-6 alkyl hydroxy) amino； (aryl) (C1-6 alkyl) amino； di (C1-6 alkyl) amino C1-6 alkyloxy； di (C1-6 alkyl) amino C1-6 alkylamino； di (C1-6 alkyl) amino C1-6 alkylamino C1-6 alkyl； arylsulfonyl； arylsulfonylamino； aryloxy； C 1-6 aryloxy alkyl； C2-6 alkenodiyl aryl； di (C1-6 alkyl) amino； di (C1-6 alkyl) amino C1-6 alkyl； di (C1-6 alkyl) amino (C1-6 alkyl) amino； di (C1-6 alkyl) amino (C1-6 alkyl) amino C1-6 alkyl； di (C1-6 alkyl) amino C1-6 alkyl (C1-6 alkyl) amino； di (C1-6 alkyl) amino C1-6 alkyl (C1-6 alkyl) amino C1-6 alkyl； aminosulfonylamino (C1-6 alkyl) amino； ami
