The present invention relates to macrolide derivatives, and to the preparation and therapeutic use thereof. The compounds according to the present invention have substantial bacteriostatic and/or bactericidal antimicrobial activity, mainly on gram-positive microorganisms. The compounds also act on mycobacteria, especially against strains of sensitive Mycobacterium or Corynebacterium that are resistant to the first-line antibiotics and in the treatment of tuberculosis. In particular, the patent application relates to compounds of formula (I) below, and to a process for preparing them and to the therapeutic use thereof.
