A medical skin applicator apparatus includes a fluid housing having afluid chamber for storing a medical agent and an applicator coupled to thehousing. Thefluid housing has a penetrable wall to permit access to the fluid chamber andrelease ofthe medical agent therefrom. The applicator includes an applicator surface forapplyingthe medical agent to a patient. The applicator has a penetrating memberadapted topenetrate the penetrable wall of the fluid housing upon achieving apredeterminedcoupled relation of the fluid housing and the applicator, to thereby permitthe medicalagent to be dispensed from the fluid chamber and applied to the patient withtheapplicator surface.