ADNAN M.M. MJALLI;JEFFREY C. WEBSTER;YE EDWARD TIAN;ROBERT ROTHLEIN
发明人:
ADNAN M.M. MJALLI,YE EDWARD TIAN,JEFFREY C. WEBSTER,ROBERT ROTHLEIN
申请号：
US12983604
公开号：
US20120171202A1
申请日:
2011.01.03
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Disclosed are RAGE fusion proteins comprising RAGE polypeptide sequences linked to a second, non-RAGE polypeptide. The RAGE fusion protein may utilize a RAGE polypeptide domain comprising a RAGE ligand binding site and an interdomain linker directly linked to an immunoglobulin CH2 domain. Such fusion proteins may provide specific, high affinity binding to RAGE ligands. Also disclosed is the use of the RAGE fusion proteins as therapeutics for RAGE-mediated pathologies.
