A method for conducting a surgical procedure is described herein. The surgical procedure includes creating a pathway through a nasal cavity, creating an opening through a section of skull that is connected to the nasal cavity, harvesting a portion of the skull formed by creating the opening to expose a dura layer of the brain, cutting a section of the dura layer to expose a section of brain tissue, and inserting a tissue resection device through the nasal cavity to take tissue samples from the exposed brain tissue. The dura layer is then secured over the exposed brain tissue so as to create a watertight seal and the previously harvested portion of the skull is inserted in in the opening and secured to the skull to close the opening.
