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THERAPEUTIC COMPOSITIONS AND METHODS FOR DELIVERY OF ACTIVE AGENTS CLEAVABLY LINKED TO NANOPARTICLES
专利权人:
Eugene Zubarev
发明人:
Eugene Zubarev,Jacob Gibson
申请号:
US13514847
公开号:
US20130004523A1
申请日:
2010.12.09
申请国别(地区):
US
年份:
2013
代理人:
摘要:
Various embodiments of the present invention pertain to therapeutic compositions that comprise: (1) an active agent (e.g., paclitaxel) and (2) a nanoparticle (e.g., gold nanoparticle). In such embodiments, the active agent is covalently linked to the nanoparticle through a cleavable linker (e.g., a linker containing a hydrazone species). Other embodiments of the present invention pertain to methods of treating a condition in a subject by administering the above-described therapeutic compositions to the subject.
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