The invention provides a method for destroying cells by metal nanoparticles upon photo irradiation comprising the following steps: irradiating with light on a metal nanoparticle at a specific wavelength transmitting a photon energy to sensitize a molecular oxygen to generate the singlet oxygen and the singlet oxygen destroys cells around the metal nanoparticles.本發明係一種利用奈米金屬顆粒進行照光以消滅細胞之方法,包括:於一溫度下照射一波長之光線於該奈米金屬顆粒;奈米金屬顆粒依據波長之光線激發一氧分子以生成一單重態氧;以及單重態氧消滅奈米金屬顆粒週圍之細胞。light‧‧‧光1 O 2‧‧‧單重態氧10‧‧‧金屬奈米顆粒