In various embodiments, the present invention provides methods of reducingthe risk of coronary revascularization in a subject on statin therapy and, inparticular, amethod of reducing the risk of a cardiovascular event in a subject on statintherapyhaving a fasting baseline triglyceride level of about 135 mg/dL to about 500mg/dL,and administering to the subject a pharmaceutical composition comprising about1 g toabout 4 g of eicosapentaenoic acid ethyl ester or a derivative thereof.