In various embodiments, the present invention provides methods of reducingthe risk of unstable angina in a subject on statin therapy and, in particular,a method ofreducing the risk of a cardiovascular event in a subject on statin therapyhaving afasting baseline triglyceride level of about 135 mg/dL to about 500 mg/dL, andadministering to the subject a pharmaceutical composition comprising about 1 gtoabout 4 g of eicosapentaenoic acid ethyl ester or a derivative thereof