The present invention relates to a celecoxib solid dispersion and its preparation method. The solid dispersion of the invention comprises of celecoxib and carrier materials selected from one or more of polyvinylpyrrolidone, copovidone, polyvinylpolypyrrolidone, and the weight ratio of scaffold material/celecoxib can be low to 0.2:1. It is prepared in the way that carrier materials and celecoxib are dissolved or dispersed in organic solvents, and then the organic solvent is removed by vacuum distillation or spray drying. The solid dispersion which is subjected to crush can be easily made into all kinds of solid dosage forms. The problem that celecoxib crude drug is difficult to smash is well solved by the invention Furthermore, the solid formulations of the invention can be made by using few materials, and have a good stability and high bioavailability.本發明涉及一種塞來昔布固體分散體及其製備方法。本發明的固體分散體，含有塞來昔布和載體材料，該載體材料選自聚乙烯吡咯烷酮、共聚維酮、交聯聚維酮中的一種或幾種，固體分散體中載體材料和塞來昔布的重量比可以低至0.2：1。其製備方法是將載體材料和塞來昔布共同溶解於有機溶劑中，或將載體材料混懸分散在塞來昔布的有機溶劑中，採用減壓乾燥或噴霧乾燥的方式除去有機溶劑即得固體分散體。該固體分散體粉碎後可以製備成各種固體製劑。本發明解決了塞來昔布原料藥難粉碎的問題，採用較少的材料即可製得性質穩定的高生物利用度固體製劑。
