Disclosed is the use of an antibody, or antigen-binding portion thereof, which binds to an epitope of the p40 subunit of IL- 12 and/or IL-23 in the manufacture of a medicament for treating plaque psoriasis in a subject, wherein the medicament is to be administered subcutaneously to the subject to provide said antibody, or antigen-binding portion thereof, in an amount of about 100 mg to about 200 mg to the subject.