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DERIVE HETEROCYCLIQUE A 5 ELEMENTS ET SES USAGES MEDICAUX
专利权人:
KISSEI PHARMACEUTICAL CO.; LTD.
发明人:
SHIMIZU, KAZUO,TAKIGAWA, YASUSHI,FUJIKURA, HIDEKI,IIZUKA, MASATO,HIRATOCHI, MASAHIRO,KIKUCHI, NORIHIKO
申请号:
CA2682393
公开号:
CA2682393C
申请日:
2008.04.10
申请国别(地区):
CA
年份:
2015
代理人:
摘要:
Disclosed is a compound useful as a prophylactic or therapeutic agent for a disease induced by abnormal plasma uric acid level or the like. Specifically disclosed is a 5-membered heterocyclic derivative represented by the general formula (I), a prodrug or salt thereof, or the like, which has a xanthine oxidase inhibitory activity and is useful as a prophylactic or therapeutic agent for a disease induced by abnormal plasma uric acid level. In the formula (I), T represents a nitro, a cyano or the like; the ring J represents an aryl or a heteroaryl; Q represents a carboxy, a 5-tetrazolyl or the like; Y represents H, OH, NH2, a halogen,a haloalkyl or the like; X1 and X2 independently represent CR2 or N; and R2 represents H, an alkyl or the like; and R1 represents a halogen, a cyano, a haloalkyl, A-D-E-G-L-M, -N(D-L-M)2 or the like [wherein A represents a single bond, O, S or the like; D, G and M independently represent an alkylene which may be substituted, a cycloalkylene, a heterocycloalkylene, an arylene, a heteroarylene or the like; and E and L independently represent a single bond, O, S, COO, SO2 or the like].
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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