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DERIVE D'(AZA)INDOLE ET SES USAGES MEDICAUX
专利权人:
KISSEI PHARMACEUTICAL CO.; LTD.
发明人:
SHIMIZU, KAZUO,TAKIGAWA, YASUSHI,FUJIKURA, HIDEKI,IIZUKA, MASATO,HIRATOCHI, MASAHIRO,KIKUCHI, NORIHIKO
申请号:
CA2682391
公开号:
CA2682391C
申请日:
2008.04.10
申请国别(地区):
CA
年份:
2014
代理人:
摘要:
The present invention provides compounds useful as agents for the preventionor treatment of a disease associated with abnormal serum uric acid level whichhas auricosuric activity or the like. The present invention relates to (aza)indolederivativesrepresented by the following general formula (I) having xanthine oxidaseinhibitoryactivities and useful as agents for the prevention or treatment of a diseaseassociatedwith abnormality of serum uric acid level, prodrugs thereof, or salts thereof.In theformula (I), T represents nitro or cyano and the like; ring J represents arylor heteroaryland the like; Q represents carboxy or 5-tetazolyl and the like; Y representsH, OH, NH2,halogen, nitro, alkyl, alkoxy and the like; X1, X2 and X3 independentlyrepresent CR2 orN; R1 and R2 independently represent halogen, cyano, haloalkyl, A-D-E-G, -N(-D-E-G)2and the like, in the formula, A represents a single bond, O, S and the like; Dand Gindependently represent optionally substituted alkylene, cycloalkylene,heterocycloalkylene, arylene, heteroarylene and the like; E represents asingle bond, O,S, COO, SO2 and the like.(see formula I)
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