HUMAN BINDING MOLECULES CAPABLE OF NEUTRALIZING INFLUENZA VIRUS H3N2 AND USES THEREOF

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专利权人:

CRUCELL HOLLAND B.V.

发明人:

THROSBY, MARK,FRIESEN, ROBERT HEINZ EDWARD,KWAKS, THEODORUS HENDRIKUS JACOBUS,JONGENEELEN, MANDY ANTONIA CATHARINA

申请号：

NZ59603210

公开号：

NZ596032A

申请日:

2010.05.06

申请国别(地区):

NZ

年份:

2013

代理人:

摘要：

NZ 596032 Disclosed is an isolated human binding molecule capable of specifically recognising and binding to an epitope in influenza haemagglutinin protein (HA), having neutralising activity against influenza viruses comprising HA of the H3 subtype, and having cross neutralising activity against at least an influenza virus comprising HA of the H7 subtype, and/or an influenza virus comprising HA of the H10 subtype, wherein the binding molecule binds to an epitope comprising the amino acid at position 19, 25, 27, 33 and/or 34 of the HA2 polypeptide of the H3 HA protein.

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