MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
发明人:
MUNOZ ALIA, MIGUEL A.,RUSSELL, STEPHEN JAMES
申请号：
CA3063690
公开号：
CA3063690A1
申请日:
2018.04.04
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
This document relates to methods and materials for making and using viruses (e.g., measles viruses or adenoviruses) having a reduced susceptibility to antibody neutralization (e.g., antibody neutralization by serum from measles virus vaccines). For example, recombinant morbilliviruses (e.g., recombinant measles viruses) having a modified H gene and a modified F gene, as well as methods of using a recombinant virus are provided.
