Mayo Foundation for Medical Education and Research
发明人:
Miguel A. Munoz Alia,Stephen James Russell
申请号：
US16612842
公开号：
US20200147204A1
申请日:
2018.04.04
申请国别(地区):
US
年份:
2020
代理人:
摘要：
This document relates to methods and materials for making and using viruses (e.g., measles viruses or adenoviruses) having a reduced susceptibility to antibody neutralization (e.g., antibody neutralization by serum from measles virus vaccines). For example, recombinant morbilliviruses (e.g., recombinant measles viruses) having a modified H gene and a modified F gene, as well as methods of using a recombinant virus are provided.
