RENSSELAER POLYTECHNIC INSTITUTE;THE ROCKEFELLER UNIVERSITY
发明人:
Sarah Stanley,Jeffrey Friedman,Jonathan S. Dordick,Jeremy Sauer
申请号：
US15464748
公开号：
US20180200386A1
申请日:
2017.03.21
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention provides methods and compositions for the remote control of cell function based on the use of a magnetic field to excite paramagnetic nanoparticles targeted to specific cell types. The cell type of interest expresses an ion channel wherein excitation of the paramagnetic nanoparticles results in a physical change that is transduced into a cellular response. Such cellular responses may include, for example, increases in gene expression resulting in production of one or more physiologically active proteins. The expression of such proteins can be used to treat a variety of different inherited or acquired diseases or disorders in a subject.
