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COMPOSITIONS AND METHODS TO MODULATE CELL ACTIVITY
专利权人:
The Rockefeller University
发明人:
Jeffrey Friedman,Sarah Stanley
申请号:
US16049102
公开号:
US20180353605A1
申请日:
2018.07.30
申请国别(地区):
US
年份:
2018
代理人:
摘要:
The present invention provides methods and compositions for the remote control of cell function based on the use of radiofrequency waves to excite nanoparticles targeted to specific cell types. The nanoparticles may be applied to the target cell extracellularly and/or expressed intracellularly. The cell type of interest expresses a temperature sensitive channel wherein excitation of the nanoparticles results in a localized temperature increase that is transduced into a cellular response. Such cellular responses may include, for example, increases in gene expression resulting in production of one or more physiologically active proteins. The expression of such proteins can be used to treat a variety of different inherited or acquired diseases or disorders in a subject. Accordingly, the invention provides a generic approach for treatment of any disease associated with a protein deficiency.
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