Disclosed is a process for the production of particles of a cefquinome acid addition salt, preferably cefquinome sulfate particles, by precipitation of cefquinome acid addition salt, preferably the sulfate, from a cefquinome betaine solution, wherein acid, preferably sulfuric acid, is added to the betaine solution. According to the invention the acid, preferably sulfuric acid, is added quickly in a single shot, in a molar excess of 40% to less than 100%. As a result, particles are formed that comprise agglomerates of microscale primary crystalline particles. This enables providing particles of cefquinome acid addition salt, preferably cefquinome sulfate, in particle sizes commensurate with micronized material, but with improved stability.揭示一種藉由從西喹諾甜菜鹼溶液沉澱西喹諾酸加成鹽(較佳是硫酸鹽)製造西喹諾酸加成鹽(較佳是西喹諾硫酸鹽)粒子的方法，其中將酸(較佳是硫酸)添加至該甜菜鹼溶液。依本發明，酸(較佳是硫酸)以40%至少於100%之莫耳過量之量被快速地以單一注射方式添加。結果，形成包含微尺度主要結晶粒子之黏聚體的粒子。此能提供粒子尺寸與微粒化材料相稱但具有改良安定性之西喹諾酸加成鹽(較佳是西喹諾硫酸鹽)粒子。
