The invention discloses the uses of hydroxyl polymethoxylflavones and/or derivative thereof that is relative to inhibte adipogenesis and lower lipid accumlation, wherein the hydroxyl polymethoxylflavones is obtained from the peels of Citrus genus plants. Therefore, the hydroxyl polymethoxylflavones that of a therapeutically effective amount not only can be a medical compound for treatment obesity or fatty liver, but also can be a food element.本發明所揭羥基多甲氧基黃酮類化合物之用途係有關於抑制脂肪生成、抑制脂肪分化及降低脂肪累積,因而羥基多甲氧基黃酮類化合物係得以一預定劑量而作為一抑制肥胖或治療脂肪肝之醫藥組合物內之有效成份,亦或得作為一食品之組成份,其中,該羥基多甲氧基黃酮類化合物係來自於一柑橘屬植物之果皮。
