COMBINATION COMPRISING AN AMINOTHIOLESTER COMPOUND OR A HARMACEUTICALLY ACCEPTABLE SALT THEREOF AND A COMPOUND ABLE TO INCREASE THE 2O2 LEVEL IN CANCER CELLS OF A SUBJECT
Ismail CEYLAN,Gerry QUASH,Mileidys PEREZ-ALEA,Guillaume MARTIN
申请号：
US15768468
公开号：
US20180303773A1
申请日:
2016.10.14
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention relates to a combination comprising an aminothiolester compound or a pharmaceutically acceptable salt thereof, in particular the S-methyl 4-(dimethylamino)-4-methylpent-2-ynethioate or a pharmaceutically acceptable salt thereof, and more particularly the 4-(Dimethylamino)-4-methyl-2-pentynethioic acid S-methyl ester fumarate, and a compound able to increase H2O2 level in cancer cells of a subject, in particular for use for the treatment of cancer in a subject, wherein cancer cells of said subject do not overproduce H2O2 in comparison to a control value and have a level of GSH below 5 nmol for 25000 cells.
