ENHANCING T-CELL FUNCTION AND TREATING A T-CELL DYSFUNCTIONAL DISORDER WITH A COMBINATION OF AN LSD INHIBITOR AND A PD1 BINDING ANTAGONIST

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专利权人:

EPIAXIS THERAPEUTICS PTY LTD

发明人:

RAO, Sudha

申请号：

SG11202004767T

公开号：

SG11202004767TA

申请日:

2018.11.28

申请国别(地区):

SG

年份:

2020

代理人:

摘要：

The present invention relates to a composition for enhancing T-cell function or for treating a T-cell dysfunctional disorder, the composition comprising, consisting or consisting essentially of a lysine specific demethylase (LSD) inhibitor (which may be a MAO inhibitor or phenelzine) and a Programmed cell death protein- 1 (PD-1) binding antagonist (which may be an antibody, preferably nivolumab, pembrolizumab, lambrolizumab or pidilizumab).

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