Randall W. King;Timothy C. Gahman;Min J. Lee;Daniel J. Finley;Byung-Hoon Lee
发明人:
Daniel J. Finley,Randall W. King,Byung-Hoon Lee,Min J. Lee,Timothy C. Gahman
申请号：
US13811129
公开号：
US08933087B2
申请日:
2011.07.22
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Proteinopathies result from the proteasome not acting efficiently enough to eliminate harmful proteins and prevent the formation of the pathogenic aggregates. As described herein, inhibition of proteasome-associated deubiquitinase Usp14 results in increased proteasome efficiency. The present invention therefore provides novel compositions and methods for inhibition of Usp14, enhancement of proteasome activity and treatment of proteinopathies.
