Finley, Daniel,King, Randall W.,Lee, Byung-Hoon,Lee, Min Jae,Gahman, Timothy C.
申请号：
AU2017204046
公开号：
AU2017204046A1
申请日:
2017.06.15
申请国别(地区):
AU
年份:
2017
代理人:
摘要：
#$%^&*AU2017204046A120170706.pdf#####Abstract Proteinopathies result from the proteasome not acting efficiently enough to eliminate harmful proteins and prevent the formation of the pathogenic aggregates. As described herein, inhibition of proteasome-associated deubiquitinase Uspl4 results in increased proteasome efficiently. The present invention therefore provides novel composition and methods for inhibition of Uspl4, enhancement of proteasome activity and treatment of proteinpathies.
