A Compound represented by the following general formula (1), salts thereof or hydrates of the foregoing is a novel compound useful for treatment and/or prevention of diseases associated with thrombus formation, and which is safer with suitable physicochemical stability. [wherein R 1a , R 1b , R 1c and R 1d each independently represent hydrogen, etc.； R 2 represents optionally substituted phenyl, etc.； R 3 represents optionally substituted C6-10 aryl, etc.； and Z 1 and Z 2 each independently represent hydrogen][式中，R1a、R1b、R1c及R1d各獨立表示氫原子等，R2表示可具有取代基之苯基等。R3表示可具有取代基之C6－10芳基等。Z1及Z2各獨立表示氫原子]。所示化合物或其鹽或彼等水合物可使用於血栓形成所引起的疾病之治療劑及/或預防劑，其具有更安全，且具有適度物理化學的安定性。
