Disclosed is a flexible surgical instrument with multiple degrees of freedom, comprising a flexible continuous body structure (10) and a drive unit (20). The flexible continuous body structure (10) comprises a distal structural body (11), a proximal structural body (16) and a middle connection body (15). The distal structural body (11) comprises a first distal structural segment (12) and a second distal structural segment (13). The proximal structural body (16) comprises a proximal structural segment. A second structural segment structural bone (163) located on the proximal structural segment and a second structural segment structural bone (133) located on the second distal structural segment (13) are fixedly connected with each other in one-to-one correspondence or are the same structural bone. The middle connection body (15) comprises channel fixing plates (152), a channel fixing block (153), a first structural bone guiding channel (151) and a second structural bone guiding channel (154). The drive unit (20) comprises a proximal structural segment drive handle (21) and a first distal structural segment drive assembly (22), the proximal structural segment drive handle (21) being fixedly connected to a proximal fixed plate (162). The first distal structural segment drive assembly (22) is located between the two channel fixing plates (152), and the output end thereof comprises two sliding blocks (228) moving in a reverse motion in a straight line. One end of a first structural segment structural bone (123) is fixedly connected to the sliding blocks (228), and the other end thereof passes through the channel fixing block (153), the first structural bone guiding channel (151) and a first distal spacer plate (121) in sequence, and is then fixedly connected to a first distal fixed plate (122).La présente invention concerne un instrument chirurgical souple présentant de multiples degrés de liberté, comprenant une structure souple continue de corps (10) et une unité d'entr