Disclosed is a flexible surgical instrument with structural bones in a crossed arrangement. The flexible surgical instrument comprises a flexible continuous body structure (10). The flexible continuous body structure (10) comprises a distal structural body (11), a proximal structural body (16) and a middle connection body (15). The distal structural body (11) comprises a first distal structural segment (12) and a second distal structural segment (13). The proximal structural body (16) comprises a proximal structural segment. A first structural segment structural bone (163) located on the proximal structure and a first structural segment structural bone (123) located on the first distal structural segment (12) are fixedly connected with each other in one-to-one correspondence or are the same structural bone. A second structural segment structural bone (164) located on the proximal structural segment and a second structural segment structural bone (133) located on the second distal structural segment (13) are fixedly connected with each other in one-to-one correspondence or are the same structural bone. The middle connection body (15) comprises two channel fixing plates (152), and a structural bone guiding channel (151) and a crossed structural bone guiding channel (153) are connected between the two channel fixing plates (152) in a fixed manner. The first structural segment structural bones (163, 123) pass through the crossed structural bone guiding channel (153), and the second structural segment structural bones (164, 133) pass through the structural bone guiding channel (151).
