The invention relates to a microcapsule structure capsulating lactic acid bacteria. The microcapsule structure includes a core layer which has lactic acid bacteria and a shell layer. The shell layer further includes a cell target layer, an acid-resistant layer and a bile-resistant layer, wherein the shell layer coated the core layer from outside to inside according to the cell target layer, the acid-resistant layer and the bile-resistant layer.本創作提供一種包覆乳酸菌之微膠囊結構體,其係包含一核心層和一殼層。核心層係含有乳酸菌,殼層具有細胞連結標靶反應層、耐胃酸層和耐膽鹽層,其中殼層係由外向內以細胞連結標靶反應層、耐胃酸層和耐膽鹽層包覆核心層。100‧‧‧包覆乳酸菌之微膠囊結構體200‧‧‧殼層210‧‧‧細胞連結標靶反應層211‧‧‧免疫原212‧‧‧多醣220‧‧‧耐胃酸層230‧‧‧耐膽鹽層300‧‧‧核心層310‧‧‧乳酸菌320‧‧‧營養因子330‧‧‧促進生長因子