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EXTRUDATES WITH NEEDLE-ACTING SUBSTANCES
专利权人:
Байер Энимэл Хельс ГмбХ (DE)
发明人:
КАНИКАНТИ Венката-Рангарао (DE),ХАМАНН Ханс-Юрген (DE),КЛЯЙНЕБУДДЕ Петер (DE),ВИТЦЛЕБ Рике (DE)
申请号:
RU2011127248/15
公开号:
RU2011127248A
申请日:
2009.11.24
申请国别(地区):
RU
年份:
2013
代理人:
摘要:
1. An extrudate containing at least one pharmaceutically active substance in the form of needles, characterized in that the ratio of the particle size of the needle-shaped pharmaceutically active substance to the diameter of the strands is at least 1: 15.2. The extrudate according to claim 1, wherein the particle size ratio of the needle-shaped pharmaceutically active substance to the diameter of the strands is at least 1: 20.3. The extrudate according to claim 1, wherein the particle size ratio of the needle-shaped pharmaceutically active substance to the diameter of the strands is at least 1: 25.4. The extrudate according to claim 1, wherein the diameter of the strands is 0.5 mm or less. 5 The extrudate according to claim 1, containing as an auxiliary substance a lipid base. The extrudate according to claim 5, containing glycerol and fatty acid esters with 12-24 carbon atoms as the lipid base. The extrudate according to claim 5, containing glycerol diester as the lipid base. The extrudate according to claim 7, containing glycerolindibehenate as the lipid base. The extrudate according to claim 5, containing glycerol triester as a lipid base. The extrudate according to claim 9, containing glycerol trimyristate, glycerol trypalmitate or glycerol tristearate as a lipid base. The extrudate of claim 10, containing glycerol tristearate as the lipid base. The extrudate according to claim 1, further comprising an antistatic agent, in particular polyethylene glycol. The extrudate according to one of claims 1 to 12, extruded below the lower boundary of the melting region of the base contained therein. The use of extrudates according to one of claims 1 to 13 for the manufacture of medicines. 15. A medicament containing an extrudate according to one of claims 1 to 13, as well as one or more pharmaceutically acceptable auxiliary1. Экструдат, содержащий по меньшей мере одно фармацевтически активное вещество в форме игл, отличающийся тем, что отношение размера частиц игловидного
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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