МЕЙЕР Штефан (CH),СЛОМИНСКИ Грег (US),ФАНКХОЙЗЕР Кристофер Эдуард (US),УИ Николь (CH)
申请号：
RU2010128245/15
公开号：
RU2010128245A
申请日:
2008.12.09
申请国别(地区):
RU
年份:
2012
代理人:
摘要：
1. A single-layer, orally disintegrating film containing at least two separate zones,! in which at least one zone (a) consists of a first composition that contains a nicotine-containing active substance, and! in which at least one zone (b) consists of a second composition that contains an alkaline substance,! and this orally disintegrating film optionally contains one or more other separate zones selected from the group of zones (a ') and (b'), moreover, zones (a ') and (b') are characterized in that they have the same composition, as well as the corresponding zones (a) and (b), respectively. ! 2. The film according to claim 1, which adheres to the mucous membrane of the cheek. ! 3. The film according to claim 1, which completely disintegrates within 1 to 10 minutes after the introduction into the oral cavity of the patient. ! 4. The film according to claim 2, which completely disintegrates within 1 to 10 minutes after injection into the oral cavity of the patient. ! 5. The film according to any one of claims 1 to 4, which provides for the coordinated release of both the nicotine-containing active substance and the alkaline substance and thereby ensures efficient and rapid absorption of the nicotine free base through the mucous membrane of the cheek. ! 6. The film according to any one of claims 1 to 4, in which the alkaline substance is selected from the group comprising sodium carbonate, potassium carbonate, sodium bicarbonate, potassium bicarbonate, sodium hydroxide, potassium hydroxide and any mixtures thereof. ! 7. The film according to any one of claims 1 to 4, in which the nicotine-containing active substance is selected from the group consisting of pharmaceutically acceptable nicotine salts, pharmaceutically acceptable nicotine complexes and pharmaceutically acceptable nicotine resinates. ! 8. The film1. Однослойная, распадающаяся при пероральном введении пленка, содержащая по меньшей мере две отдельные зоны, ! в которой по меньшей мере одна зона (а) состоит
