COMPOSITIONS AND METHODS FOR REGULATING CAR T CELLS

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专利权人:

THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

发明人:

JUNE CARL H.,LEVINE BRUCE L.,KALOS MICHAEL D.

申请号：

IN10889DEN2014

公开号：

IN10889DEN2014A

申请日:

2014.12.19

申请国别(地区):

IN

年份:

2015

代理人:

摘要：

The invention provides a method for inhibiting the depletion of healthy tissue during CAR T cell therapy comprising administering a drug molecule conjugate comprising a drug and a molecule to a subject receiving CAR T cell therapy wherein the molecule binds to a CAR expressed on the surface of a T cell. The invention relates to binding of the conjugate to the CAR resulting in internalization of the conjugate into the cell and drug mediated death of the cell.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/