Compositions and methods for regulating CAR T cells

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专利权人:

The Trustees of the University of Pennsylvania

发明人:

June, Carl H.,Levine, Bruce L.,Kalos, Michael D.

申请号：

AU2013289970

公开号：

AU2013289970A1

申请日:

2013.07.12

申请国别(地区):

AU

年份:

2015

代理人:

摘要：

The invention provides a method for inhibiting the depletion of healthy tissue during CAR T cell therapy comprising administering a drug-molecule conjugate comprising a drug and a molecule to a subject receiving CAR T cell therapy, wherein the molecule binds to a CAR expressed on the surface of a T cell. The invention relates to binding of the conjugate to the CAR resulting in internalization of the conjugate into the cell and drug-mediated death of the cell.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/