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Gastric retentive extended release pharmaceutical compositions
专利权人:
发明人:
Krishna R. Devarakonda,Michael J. Giuliani,Vishal K. Gupta,Ralph A. Heasley,Susan Shelby
申请号:
US14132500
公开号:
US08790694B2
申请日:
2013.12.18
申请国别(地区):
US
年份:
2014
代理人:
摘要:
The present disclosure provides extended release pharmaceutical compositions comprising an opioid and an additional active pharmaceutical ingredient, wherein the composition exhibits gastric retentive properties which are achieved by a combination of a physical property of the composition and release of the opioid, wherein upon administration to a subject, the composition has at least one pharmacokinetic parameter that differs by less than about 30% when the subject is in a fasted state as compared to a fed state.
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