Krishna R. Devarakonda,Michael J. Giuliani,Vishal K. Gupta,Ralph A. Heasley,Susan Shelby
申请号：
US14132500
公开号：
US08790694B2
申请日:
2013.12.18
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present disclosure provides extended release pharmaceutical compositions comprising an opioid and an additional active pharmaceutical ingredient, wherein the composition exhibits gastric retentive properties which are achieved by a combination of a physical property of the composition and release of the opioid, wherein upon administration to a subject, the composition has at least one pharmacokinetic parameter that differs by less than about 30% when the subject is in a fasted state as compared to a fed state.
