KRISHNA R. DEVARAKONDA,MICHAEL J. GIULIANI,VISHAL K. GUPTA,RALPH A. HEASLEY,SUSAN SHELBY
申请号：
US15147621
公开号：
US20160243041A1
申请日:
2016.05.05
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present disclosure provides extended release pharmaceutical compositions comprising an opioid and an additional active pharmaceutical ingredient, wherein the composition exhibits gastric retentive properties which are achieved by a combination of a physical property of the composition and release of the opioid, wherein upon administration to a subject, the composition has at least one pharmacokinetic parameter that differs by less than about 30% when the subject is in a fasted state as compared to a fed state.
