STEVENS SEAN,MURPHY ANDREW J.,WANG LI-HSIEN,DORE JR. ANTHONY T.
申请号：
NZ70943212
公开号：
NZ709432A
申请日:
2012.10.29
申请国别(地区):
NZ
年份:
2015
代理人:
摘要：
Disclosed is a genetically modified murine comprising a replacement at an endogenous murine IL-6 locus of a murine gene encoding IL-6 with a human gene encoding human IL-6, wherein the human gene encoding human IL-6 is under control of endogenous murine regulatory elements at the endogenous murine IL-6 locus, and wherein the murine animal is not a mouse. Also disclosed is a genetically modified murine animal, comprising a humanisation of an endogenous murine IL-6R&alpha； gene, wherein the humanisation comprises a replacement of murine IL-6R&alpha； ectodomain-encoding sequence with human IL-6R&alpha； ectodomain-encoding sequence at the endogenous murine IL-6R&alpha； locus, and wherein the humanised IL-6R&alpha； gene is under control of endogenous murine regulatory elements, and wherein the murine animal is not a mouse.
