ANDERSON, ANNALIESA SYBIL,ARUMUGHAM, RASAPPA GOUNDER,FARLEY, JOHN ERWIN,FLETCHER, LEAH DIANE,HARRIS, SHANNON,JANSEN, KATHRIN UTE,JONES, THOMAS RICHARD,KHANDKE, LAKSHMI,LOUN, BOUNTHON,PEREZ, JOHN LANCE
申请号：
CA2923129
公开号：
CA2923129C
申请日:
2014.08.27
申请国别(地区):
CA
年份:
2020
代理人:
摘要：
In one aspect, the invention relates to a composition including a first polypeptide having the sequence set forth in SEQ ID NO: 1 and a second polypeptide having the sequence set forth in SEQ ID NO: 2. In one embodiment, the composition includes about 120 µg/ml of a first polypeptide including the amino acid sequence set forth in SEQ ID NO: 1, 120 µg/ml of a second polypeptide including the amino acid sequence set forth in SEQ ID NO: 2, about 2.8 molar ratio polysorbate-80 to the first polypeptide, about 2.8 molar ratio polysorbate-80 to the second polypeptide, about 0.5 mg/ml aluminum, about 10 m M histidine, and about 150 m M sodium chloride. In one embodiment, a dose of the composition is about 0.5 ml in total volume. In one embodiment, two-doses of the composition induce a bactericidal titer against diverse heterologous subfamily A and subfamily B strains in a human.
