ANDERSON ANNALIESA SYBIL,ARUMUGHAM RASAPPA GOUNDER,FARLEY JOHN ERWIN,FLETCHER LEAH DIANE,HARRIS SHANNON,JANSEN KATHRIN UTE,JONES THOMAS RICHARD,KHANDKE LAKSHMI,LOUN BOUNTHON,PEREZ JOHN LANCE,ZLOTNICK
申请号：
IN201717027209
公开号：
IN201717027209A
申请日:
2017.07.31
申请国别(地区):
IN
年份:
2018
代理人:
摘要：
In one aspect the invention relates to a composition including a first polypeptide having the sequence set forth in SEQ ID NO: 1 and a second polypeptide having the sequence set forth in SEQ ID NO: 2. In one embodiment the composition includes about 120 µg/ml of a first polypeptide including the amino acid sequence set forth in SEQ ID NO: 1 120 µg/ml of a second polypeptide including the amino acid sequence set forth in SEQ ID NO: 2 about 2.8 molar ratio polysorbate 80 to the first polypeptide about 2.8 molar ratio polysorbate 80 to the second polypeptide about 0.5 mg/ml aluminum about 10 m M histidine and about 150 m M sodium chloride. In one embodiment a dose of the composition is about 0.5 ml in total volume. In one embodiment two doses of the composition induce a bactericidal titer against diverse heterologous subfamily A and subfamily B strains in a human.
